Vegas Odds for Clemson-Louisville

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Clemson (2-0, 0-0 ACC) opened as a pick-em versus Louisville for Thursday's 7:30 p.m. contest on ESPN at Papa John's Cardinal Stadium in Louisville, Kentucky.

The line has moved higher for the Tigers to -3.5 since its opening on Sunday because of early betting for the Tigers.

Clemson defeated App State 41-10 in front of a sellout crowd in Death Valley on Saturday afternoon while Louisville struggled at home falling to Houston 34-31. The Cardinals will look to avoid a 0-3 start to the season.

Update 8 PM EST: Clemson is now favored by five points.

Monday Update: Clemson is now a six point favorite.

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