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Topic: some good news about two new antiviral oral drugs
Replies: 3   Last Post: Oct 2, 2021, 10:14 AM by: Tropical
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some good news about two new antiviral oral drugs


Oct 1, 2021, 2:23 PM
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from Merck and Pfizer. They might be coming in to play soon, tests look promising.

Pfizer's new drug therapy is a protease inhibitor that is very similar to an HCV compound approved in 2011 called Boceprevir. Protease inhibitors often work because they can be effective disruptors of the main enzyme virus' need to replicate. In sars-cov2 The enzyme is called 3CLpro.

It's like the horse paste, lol.


https://www.acsh.org/news/2021/09/29/pfizers-covid-pill-ought-work-heres-why-and-some-good-news-about-mercks-molnupiravir-15835


https://www.nature.com/articles/s42003-020-01577-x


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That is good news. In light of this...


Oct 2, 2021, 6:30 AM
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I pay special attention to studies not done by Pfizer. Cracks me up when someone cites a Pfizer study on the vaccine they want to sell. Most studies list conflicts of interest. Israel has done some as well showing the same thing. Pfizer finally admitted what Israel found. But has anyone seen the Pfizer study? In fact the FDA won't approve the boosters because they're waiting on more data from..... Pfizer.

Anyway.... This one seems well done. It is interesting to note the mRNA antibodies are actually highly effective against Delta. More than several other strains. But they decline more rapidly over time with delta than any other variant.

And of course what's missing.... This same study on people who got covid and natural immunity. When something isn't done that should be... You can assume it's not good news. Also interesting they measured T cell response as well as antibodies. T cell response could be an area where natural immunity shines. Because it doesn't with the vaccines. Where are the studies like this on the millions of recovered people?

Treatment is a better hope than vaccines IMO. This isn't a vaccine preventable disease. It isn't a vaccine stopping disease. At this point vaccines only help you survive it without a hospital bed. I'm sure there are treatments similarly effective. Combined may be even better.

https://www.biorxiv.org/content/10.1101/2021.09.30.462488v1.full.pdf+html

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Tough times create strong men.
Strong men create easy times.
Easy times create weak men.
Weak men create tough times.


So why do the vaccinated care


Oct 2, 2021, 7:26 AM
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SO MUCH about the unvaccinated?

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Short term hospital ICU availability. Long term health care costs.

[2]
Oct 2, 2021, 10:14 AM
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Vaccines reduce hospitalizations / deaths but do not prevent infection. Therapeutics help reduce severity.

Hospitalizations will decrease due to both _ so the short term impact will pass; perhaps already seeing that trend.

I have some personal experience with ICU availability. Fortunately there was a good outcome when an ICU nurse came in (his choice) on a Saturday night to stay with a grandchild who had a skull fracture / concussion. If this nurse didn’t come in, the child was going to be transferred to another hospital a good distance away. Just one anecdotal story.

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