Cliff Austin ran for two touchdowns, and Donald Igwebuike kicked two field goals as Clemson rolled.
Austin, the game's leading rusher, carried 14 times for 89 yards, and Clemson's quarterback, Homer Jordan, completed 9 of 16 passes for 161 yards in the Tigers' first Atlantic Coast Conference game this season. Clemson had 426 yards total offense.
Clemson, first in the nation in scoring defense, improved its record to 5-0. The injury-plagued Cavaliers lost their fifth straight game.